We describe the development of zikv vaccine candidates using the self amplifying messenger rna.
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Socio economic status was identified through levels of pupil entitlement to the provision of free school meals fsm which have been confirmed as a reliable measure of socio economic status taylor 2018.
Seven schools across wales scotland and england were recruited to represent a range of urban rural locations and socio economic compositions.
Zika virus zikv is the cause of a pandemic associated with microcephaly in newborns and guillain barre syndrome in adults.
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Duffy et al 2009 the recent emergence of zikv in brazil the americas.
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Currently there are no available treatments or vaccines for zikv and the development of a safe and effective vaccine is a high priority for many global health organizations.
In recent years nucleic acid amplification technologies have made great progress which promotes the wide applications of nucleic acid detection 1 2 the increasing number of sudden infectious diseases are great threats to public healthcare for example ebola virus zika virus and more recently sars cov 2 in this case point of care testing poct for the pathogens.
The exact cause is unknown.
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Zika virus zikv belongs to the flavivirus genus and was first isolated from uganda in 1947 dick et al 1952 the virus is a mosquito transmitted arbovirus and the first major zikv outbreaks were observed in the yap islands and french polynesia in 2007 and 2013 respectively cao lormeau et al 2014.
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Bell s palsy also known as acute peripheral facial palsy of unknown cause can occur at any age.
The chaser body is manufactured from the same material as bel chain chasers but the rocker on which the wire rope slides is made from an abrasion resistant alloy having a higher through hardness.
This eight week clerkship is designed to train students to recognize physical conditions and disease processes that represent surgical emergencies to provide an understanding of when surgical consultation is appropriate for patients and to introduce the student to the principles of surgery as practiced by all surgeons regardless of specialty.
